Nemu Kurotsuchi (涅 ネム, Kurotsuchi Nemu?) is the lieutenant of the 12th Division. She is the artificially created daughter of Mayuri Kurotsuchi, a combination of his research in artificial bodies (義骸, gigai?) and artificial souls (義魂, gikon?).[20] This past has driven her to become rather introverted and melancholic, preferring to stay silent in her captain's presence. Their relationship is far from the average father-daughter one, as Mayuri doesn't seem to care much for Nemu's well-being (even using her as bait in combat). The most that can be said in his favor is that he has occasionally implied concern over her life as a point of personal pride in his own skill as her creator. Despite being abused and mistreated in every possible way by her father, Nemu still shows great loyalty to him, and has openly expressed worry at the prospect of his death. Unlike her father, however, she seems to have compassion for others, saving Uryū Ishida's life as thanks when he does not kill Mayuri.

Nemu's body was designed to withstand fatal wounds, though she still suffers the pain brought on by her injuries. This extends to being able to survive impregnation by Szayel Aporro Granz, a process meant to bring him back to life while leaving her as an empty husk. Mayuri can repair Nemu very quickly in these situations, allowing her to continue doing her father's bidding. Nemu is also immune to Mayuri's many poisons. Despite this, she carries around a variety of antidotes to be used as she sees fit. She also holds various poisons and potions derived from Mayuri's research in her own body, making her highly dangerous to those that attack her internally. Nemu does not normally carry a zanpakutō, but she is shown to have one in an illustration in the artbook "All Color but the Black". Her zanpakutō takes the form of what appears to be a thin katana.